Therapeutic differentiation and maturation of lymphatic vessels after lymph node dissection and transplantation.
Identifieur interne : 007071 ( Main/Exploration ); précédent : 007070; suivant : 007072Therapeutic differentiation and maturation of lymphatic vessels after lymph node dissection and transplantation.
Auteurs : Tuomas Tammela [Finlande] ; Anne Saaristo ; Tanja Holopainen ; Johannes Lyytikk ; Anna Kotronen ; Miia Pitkonen ; Usama Abo-Ramadan ; Seppo Yl Herttuala ; Tatiana V. Petrova ; Kari Alitalo [Finlande]Source :
- Nature medicine [ 1546-170X ] ; 2007.
Descripteurs français
- KwdFr :
- Animaux, Communication cellulaire, Différenciation cellulaire, Facteur de croissance endothéliale vasculaire de type C (métabolisme), Facteur de croissance endothéliale vasculaire de type D (métabolisme), Humains, Lymphadénectomie, Lymphoedème (anatomopathologie), Lymphoedème (immunologie), Métastase tumorale, Noeuds lymphatiques (transplantation), Protéines et peptides de signalisation intercellulaire (métabolisme), Régulation de l'expression des gènes, Souris, Tumeurs (immunologie), Vaisseaux lymphatiques (physiologie).
- MESH :
- anatomopathologie : Lymphoedème.
- immunologie : Lymphoedème, Tumeurs.
- métabolisme : Facteur de croissance endothéliale vasculaire de type C, Facteur de croissance endothéliale vasculaire de type D, Protéines et peptides de signalisation intercellulaire.
- physiologie : Vaisseaux lymphatiques.
- transplantation : Animaux, Communication cellulaire, Différenciation cellulaire, Humains, Lymphadénectomie, Métastase tumorale, Noeuds lymphatiques, Régulation de l'expression des gènes, Souris.
English descriptors
- KwdEn :
- Animals, Cell Communication, Cell Differentiation, Gene Expression Regulation, Humans, Intercellular Signaling Peptides and Proteins (metabolism), Lymph Node Excision, Lymph Nodes (transplantation), Lymphatic Vessels (physiology), Lymphedema (immunology), Lymphedema (pathology), Mice, Neoplasm Metastasis, Neoplasms (immunology), Vascular Endothelial Growth Factor C (metabolism), Vascular Endothelial Growth Factor D (metabolism).
- MESH :
- chemical , metabolism : Intercellular Signaling Peptides and Proteins, Vascular Endothelial Growth Factor C, Vascular Endothelial Growth Factor D.
- immunology : Lymphedema, Neoplasms.
- pathology : Lymphedema.
- physiology : Lymphatic Vessels.
- transplantation : Lymph Nodes.
- Animals, Cell Communication, Cell Differentiation, Gene Expression Regulation, Humans, Lymph Node Excision, Mice, Neoplasm Metastasis.
Abstract
Surgery or radiation therapy of metastatic cancer often damages lymph nodes, leading to secondary lymphedema. Here we show, using a newly established mouse model, that collecting lymphatic vessels can be regenerated and fused to lymph node transplants after lymph node removal. Treatment of lymph node-excised mice with adenovirally delivered vascular endothelial growth factor-C (VEGF-C) or VEGF-D induced robust growth of the lymphatic capillaries, which gradually underwent intrinsic remodeling, differentiation and maturation into functional collecting lymphatic vessels, including the formation of uniform endothelial cell-cell junctions and intraluminal valves. The vessels also reacquired pericyte contacts, which downregulated lymphatic capillary markers during vessel maturation. Growth factor therapy improved the outcome of lymph node transplantation, including functional reconstitution of the immunological barrier against tumor metastasis. These results show that growth factor-induced maturation of lymphatic vessels is possible in adult mice and provide a basis for future therapy of lymphedema.
DOI: 10.1038/nm1689
PubMed: 18059280
Affiliations:
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Petrova</name></author><author><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name><affiliation><country>Finlande</country><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName></affiliation></author></analytic><series><title level="j">Nature medicine</title><idno type="eISSN">1546-170X</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cell Communication</term><term>Cell Differentiation</term><term>Gene Expression Regulation</term><term>Humans</term><term>Intercellular Signaling Peptides and Proteins (metabolism)</term><term>Lymph Node Excision</term><term>Lymph Nodes (transplantation)</term><term>Lymphatic Vessels (physiology)</term><term>Lymphedema (immunology)</term><term>Lymphedema (pathology)</term><term>Mice</term><term>Neoplasm Metastasis</term><term>Neoplasms (immunology)</term><term>Vascular Endothelial Growth Factor C (metabolism)</term><term>Vascular Endothelial Growth Factor D (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Communication cellulaire</term><term>Différenciation cellulaire</term><term>Facteur de croissance endothéliale vasculaire de type C (métabolisme)</term><term>Facteur de croissance endothéliale vasculaire de type D (métabolisme)</term><term>Humains</term><term>Lymphadénectomie</term><term>Lymphoedème (anatomopathologie)</term><term>Lymphoedème (immunologie)</term><term>Métastase tumorale</term><term>Noeuds lymphatiques (transplantation)</term><term>Protéines et peptides de signalisation intercellulaire (métabolisme)</term><term>Régulation de l'expression des gènes</term><term>Souris</term><term>Tumeurs (immunologie)</term><term>Vaisseaux lymphatiques (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Intercellular Signaling Peptides and Proteins</term><term>Vascular Endothelial Growth Factor C</term><term>Vascular Endothelial Growth Factor D</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Lymphoedème</term><term>Tumeurs</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Lymphedema</term><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteur de croissance endothéliale vasculaire de type C</term><term>Facteur de croissance endothéliale vasculaire de type D</term><term>Protéines et peptides de signalisation intercellulaire</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Lymphatic Vessels</term></keywords><keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>Lymph Nodes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Communication</term><term>Cell Differentiation</term><term>Gene Expression Regulation</term><term>Humans</term><term>Lymph Node Excision</term><term>Mice</term><term>Neoplasm Metastasis</term></keywords><keywords scheme="MESH" qualifier="transplantation" xml:lang="fr"><term>Animaux</term><term>Communication cellulaire</term><term>Différenciation cellulaire</term><term>Humains</term><term>Lymphadénectomie</term><term>Métastase tumorale</term><term>Noeuds lymphatiques</term><term>Régulation de l'expression des gènes</term><term>Souris</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Surgery or radiation therapy of metastatic cancer often damages lymph nodes, leading to secondary lymphedema. Here we show, using a newly established mouse model, that collecting lymphatic vessels can be regenerated and fused to lymph node transplants after lymph node removal. Treatment of lymph node-excised mice with adenovirally delivered vascular endothelial growth factor-C (VEGF-C) or VEGF-D induced robust growth of the lymphatic capillaries, which gradually underwent intrinsic remodeling, differentiation and maturation into functional collecting lymphatic vessels, including the formation of uniform endothelial cell-cell junctions and intraluminal valves. The vessels also reacquired pericyte contacts, which downregulated lymphatic capillary markers during vessel maturation. Growth factor therapy improved the outcome of lymph node transplantation, including functional reconstitution of the immunological barrier against tumor metastasis. These results show that growth factor-induced maturation of lymphatic vessels is possible in adult mice and provide a basis for future therapy of lymphedema.</div></front></TEI><affiliations><list><country><li>Finlande</li></country><region><li>Uusimaa</li></region><settlement><li>Helsinki</li></settlement><orgName><li>Université d'Helsinki</li></orgName></list><tree><noCountry><name sortKey="Abo Ramadan, Usama" sort="Abo Ramadan, Usama" uniqKey="Abo Ramadan U" first="Usama" last="Abo-Ramadan">Usama Abo-Ramadan</name><name sortKey="Holopainen, Tanja" sort="Holopainen, Tanja" uniqKey="Holopainen T" first="Tanja" last="Holopainen">Tanja Holopainen</name><name sortKey="Kotronen, Anna" sort="Kotronen, Anna" uniqKey="Kotronen A" first="Anna" last="Kotronen">Anna Kotronen</name><name sortKey="Lyytikk, Johannes" sort="Lyytikk, Johannes" uniqKey="Lyytikk J" first="Johannes" last="Lyytikk">Johannes Lyytikk</name><name sortKey="Petrova, Tatiana V" sort="Petrova, Tatiana V" uniqKey="Petrova T" first="Tatiana V" last="Petrova">Tatiana V. Petrova</name><name sortKey="Pitkonen, Miia" sort="Pitkonen, Miia" uniqKey="Pitkonen M" first="Miia" last="Pitkonen">Miia Pitkonen</name><name sortKey="Saaristo, Anne" sort="Saaristo, Anne" uniqKey="Saaristo A" first="Anne" last="Saaristo">Anne Saaristo</name><name sortKey="Yl Herttuala, Seppo" sort="Yl Herttuala, Seppo" uniqKey="Yl Herttuala S" first="Seppo" last="Yl Herttuala">Seppo Yl Herttuala</name></noCountry><country name="Finlande"><region name="Uusimaa"><name sortKey="Tammela, Tuomas" sort="Tammela, Tuomas" uniqKey="Tammela T" first="Tuomas" last="Tammela">Tuomas Tammela</name></region><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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